library.onepin.app/nandrolone-decanoate Peptide Education Library
Education only, not medical advice 21+ Every dose is an example to finalize with a licensed provider
Hormonal FDA-approved medicineControlled substancePrescription drug

Nandrolone Decanoate

Deca-Durabolin · Deca · Nandro

50-200mg – 300-600 mg IM every 1-2 weeks

Nandrolone Decanoate (brand name Deca-Durabolin) is an injectable anabolic-androgenic steroid (AAS) consisting of nandrolone (19-nortestosterone) esterified with decanoic acid. It is FDA-approved for the treatment of anemia associated with chronic kidney disease. Nandrolone was first synthesized in 1950 and the decanoate ester was introduced commercially in 1962. It remains one of the most widely studied and prescribed anabolic steroids worldwide.

Quick Start
Route
Intramuscular (IM)
Start low
50-200mg IM
Frequency
every 1-2 weeks
Timing
No specific requirement

Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.

Tiered Protocols · lowest first
Conservative start
50-200mg · Intramuscular (IM) · every 1-2 weeks
conservative starter
50-200mg
every 1-2 weeks
Intermediate
Joint Preservation / TRT Adjunct
100-150 mg · IM · Weekly
human clinical trial · FDA Deca-Durabolin label
Always stack with a testosterone base to maintain estrogen levels and sexual function. Promotes synovial fluid retention.
100-150 mg
Weekly
Expert
Hypertrophy Phase
300-600 mg · IM · Weekly
anecdotal · community
Long ester (Decanoate) takes 4-6 weeks to reach steady state. Highly suppressive to the HPTA.
300-600 mg
Weekly
01

How it works

Binds to androgen receptors in muscle and bone tissue, promoting protein synthesis, nitrogen retention, and muscle hypertrophy with a high anabolic-to-androgenic ratio.

Stimulates collagen synthesis and increases bone mineral density by promoting osteoblast activity and calcium retention, contributing to joint and skeletal health.

Increases erythropoietin production and red blood cell mass, which is the basis for its FDA-approved indication in anemia of chronic kidney disease.

02

What to expect

Early
Days 1–7

Weeks 1-3: Minimal effects as the long decanoate ester slowly builds blood levels. Some increased appetite and well-being.

03

Evidence

HumanPresent
AnimalStrong
In-vitroPresent

References for this compound are being re-checked against their source records. We are not showing them until each one is confirmed to support the claim it sits under.

04

Interactions & stacking

Two different questions: what is documented about running these together, and what is documented about drawing them into the same syringe. A good pharmacological partner can still have to be pinned separately.

Documented together

AnastrozoleAI can manage estrogen-related side effects when using nandrolone alongside testosterone
HCGHCG maintains testicular function during nandrolone use to mitigate suppression
MK-677GH secretagogue and anabolic steroid support body composition through independent pathways
Pentosan PolysulfateBoth support joint health - nandrolone via collagen, PPS via GAG layer and cartilage protection

Keep separate

TriptorelinGnRH agonist suppresses HPG axis, conflicting with anabolic steroid use - triptorelin is used for PCT after steroid cessation, not during
EnclomipheneSERM aims to restore natural testosterone production, which nandrolone suppresses - contradictory goals

Check any specific pair in the Stack & Interaction Checker, which answers both questions separately. Absence of a documented conflict is not evidence of safety.

05

Pharmacokinetics

Illustrative plasma concentration · 38 d
Half-life
~6-12 days

Decanoate ester

Peak · Tmax
~24-48 hours

IM (oil depot)

Elimination
~30-60 days

Metabolites detectable in urine up to 18 months.

Bioavailability
~100%

IM (oil-based depot injection, complete absorption over time)

Duration of action
7-14 days

Per injection (supports weekly to biweekly dosing)

Clearance

Hepatic (ester hydrolysis then phase I/II metabolism); renal excretion of metabolites

Storage. Store at room temperature (20-25C). Protect from light. Oil-based solution - no reconstitution needed.

06

Regulatory status

FDA-approved (Deca-Durabolin) for anemia of chronic renal failure. Schedule III controlled substance (US). Prescription required. Banned in most competitive sports (WADA prohibited list).

Put it to work

Calculate, log & track

Open Nandrolone Decanoate straight into OnePin with your vial and dose pre-filled, then let it handle the syringe math and remind you before the vial runs out.

Open Nandrolone Decanoate in the app →

Go deeper

The guide & community

The complete Nandrolone Decanoate walkthrough, real protocol discussion and coaching live inside the BlessUp community on Skool.

Join the community ↗
Open in app Community

Track it in OnePin. Log vials, draws, and protocols in the app.