Oxandrolone · Anavar 10mg
Oxandrolone (Anavar) is a synthetic oral anabolic-androgenic steroid, a C17-alpha-alkylated derivative of dihydrotestosterone (DHT). First synthesized in 1962, it was originally developed to help regain weight after extensive surgery, chronic infection, severe trauma, and to offset protein catabolism from prolonged corticosteroid use. Among the AAS class it is considered one of the mildest in terms of androgenic side effects while offering meaningful anabolic activity, with an anabolic-to-androgenic ratio estimated at 322-630:24.
Take with food to reduce GI upset. Split daily dose into morning and evening for more stable blood levels given the 9-10 hour half-life. Do not take at bedtime - may affect sleep in sensitive individuals. Always pair with regular liver enzyme monitoring (ALT/AST, GGT).
Start here. Every protocol below is ordered lowest-first. Begin at the smallest effective dose, hold about a week to assess tolerance, and step up only if needed.
Oxandrolone binds the androgen receptor (AR) in skeletal muscle and other tissues, promoting protein synthesis and nitrogen retention. Compared to testosterone, DHT-derived oxandrolone has negligible affinity for the estrogen receptor, so it does not aromatize and does not produce estrogen-related side effects such as gynecomastia or water retention.
The C17-alpha-alkyl group protects the molecule from first-pass hepatic metabolism, giving it high oral bioavailability (~97%) but also imparting hepatotoxicity - the same structural feature that lets it survive the liver also stresses hepatocytes. Effects on cholesterol (HDL suppression, LDL elevation) are typical of the oral steroid class.
At therapeutic doses it suppresses endogenous testosterone production via negative feedback on the HPT axis, so extended use without a testosterone base is discouraged in men who want to preserve natural production.
First 1-2 weeks: mild strength improvements noticeable in compound lifts. Appetite may decrease. No significant scale weight change - the drug supports muscle retention rather than rapid mass gain.
Weeks 3-5: visible body composition changes, muscle hardness, and pump enhancement during training. Strength gains plateau but hold steady. Liver enzymes should be checked at this point.
Weeks 6-8: peak benefits typically realized. Continued use beyond 8 weeks offers diminishing returns and escalating hepatic / lipid risk. Plan a cycle-off period at least equal to the on period.
Each reference below was re-fetched from its PubMed record, and the quoted sentence was confirmed to appear in that abstract and to support the claim it sits under. Follow any of them to read the source.
Dose/effect: pediatric burn patients received 0.1 mg/kg orally twice daily and improved muscle protein net balance.
Subjects were studied 5 to 7 days after admission, and again after 1 week of oxandrolone treatment at 0.1 mg/kg by mouth twice daily or no pharmacologic treatment.
Anabolic effects of oxandrolone after severe burn.
Evidence scope. Human, pediatric (14 severely burned children); oral; 1-week treatment; prospective cohort study (not randomized).
Mechanism/effect: oxandrolone improved muscle protein metabolism through increased protein-synthesis efficiency in severe burns.
In burn victims, oxandrolone improves muscle protein metabolism through enhanced protein synthesis efficiency.
Anabolic effects of oxandrolone after severe burn.
Evidence scope. Same pediatric burn cohort as the paired dose/effect row above; mechanism specifically = protein-synthesis efficiency, measured via stable-isotope kinetics.
Dose/route: adult burn studies used oxandrolone 10 mg orally twice daily, directly supporting the card’s 10 mg oral starting dose and twice-daily option.
In clinical studies, oxandrolone 10 mg orally twice/day improved wound healing, restored lean body mass, and accelerated body weight gain.
Oxandrolone treatment in adults with severe thermal injury.
Evidence scope. Human adults; severe thermal injury; narrative review noting most underlying data come from small, single-center studies (the source's own caveat) — not this paper's own controlled trial.
Long-term safety boundary: a pediatric randomized trial reported no attributed adverse effects during long-term oxandrolone administration.
No adverse side effects were attributed to the long-term administration of oxandrolone.
Evidence scope. Human, pediatric (severely burned children); randomized clinical trial; oral 0.1 mg/kg twice daily for up to 24 months.
Primary safety: a systematic review found no increase in progressive or transient liver injury but still recommended liver-enzyme monitoring.
It does not appear that Oxandrolone increases the risk of progressive or transient liver injury, although monitoring liver enzymes is recommended.
Oxandrolone in the Treatment of Burn Injuries: A Systematic Review and Meta-analysis.
Evidence scope. Human; systematic review/meta-analysis of 31 studies; burn patients (the review explicitly excluded basic-science and animal studies).
Claims we could not support
No abstract we checked supports these for this molecule at this route. That is not the same as saying they are false — it marks where the evidence is missing.
Card-specific lipid claim (HDL suppression / LDL elevation) at 10-50 mg/day. The selected exact-route abstracts support oral dose, anabolic effect, and liver monitoring but do not state the card’s quantified lipid concern.
Oral
Per dose - supports once or twice daily dosing
Hepatic (CYP3A4, CYP2C9). Renal excretion of metabolites.
Storage. Store at controlled room temperature (20-25°C / 68-77°F). Protect from moisture and light. Keep in original container with desiccant when available. Shelf life typically 3 years from manufacture date. Keep out of reach of children and in a locked location - Schedule III controlled substance in the United States.
Schedule III controlled substance in the United States under the Anabolic Steroids Control Act of 1990. Requires prescription. FDA-approved brand names include Oxandrin (Savient / BTG). Generic oxandrolone is also available. Internationally classified similarly in most jurisdictions. Possession or distribution without a valid prescription is a federal offense in the United States.
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